rapid single-nucleotide polymorphism detection of vitamin k epoxide reductase (vkorc1) genes in an iranian population using taqman genotyping assay

Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2.

BACKGROUND Polymorphisms of the CYP2C9 (cytochrome P450, family 2, subfamily C, polypeptide 9) gene (CYP2C9*2, CYP2C9*3) and the VKORC1 (vitamin K epoxide reductase complex, subunit 1) gene (-1639G>A) greatly impact the maintenance dose for the drug warfarin. Prescreening patients for their genotypes before prescribing the drug facilitates a faster individualized determination of the proper mai...

frequency of single nucleotide polymorphisms of cytochrome p450 cyp2c9 in an iranian population using taqman genotyping assay

allele and genotype frequencies of single nucleotide polymorphisms of cytochrome p450 cyp2c19 in an iranian population using taqman genotyping assay

allele frequencies of single nucleotide polymorphisms of cytochrome p450 cyp2c8 in an iranian population using taqman genotyping assay

Vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphisms in population of Eastern Croatia.

Vitamin K epoxide reductase (VKOR) is a key enzyme in the y-carboxylation of proteins associated with important bodily functions (coagulation, bone metabolism, etc.). This feature is particularly used in warfarin therapy, which blocks the VKOR enzyme and leads to production of dysfunctional coagulation proteins. Genetic factors, particularly vitamin K epoxide reductase complex 1 (VKORC1) gene, ...

Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Polymorphism and Aortic Calcification

Objective—Besides effects on hemostasis, vitamin K-dependent proteins play a role in bone mineralization and arterial calcification. We investigated the association between the VKORC1 1173C T polymorphism and calcification of the aortic far wall in a large population-based cohort. Methods and Results—Aortic calcification was diagnosed by radiographic detection of calcified deposits in the abdom...